Macrophage activation is an immunotherapeutic approach that reinforces the immune system and helps it to fight cancer; it also has a direct effect on cancer cells in vitro and therefore it can be proposed as an effective anticancer approach. 

Macrophage activation's best effects are observed when it is administered in early stages of cancer when there is not yet the need of conventional therapies. However, several Doctors in the world have observed significant effects also in advanced cancers and after other conventional treatments such as surgery, radio- or chemo-therapy.

Yamamoto’s three cancer studies showed that incredibly small weekly doses (100 billionths of a gram—an amount that is invisible to the naked eye) of Macrophage activation had cured early metastatic breast, prostate, and colon cancers in 100% of (nonanemic) patients. In a fourth paper, he used the same treatment to cure 100% of nonanemic HIV-infected patients.

 For the three cancer studies, Dr. Yamamoto had chosen patients who had recently received the standard mainstream triad of surgery, chemo, and radiation. Despite these treatments, every patient had evidence of metastatic disease, which means that despite the best efforts of conventional medicine, their cancers were out of control and still growing. Their prognoses were poor at best. Nevertheless, this patient group had one thing in common: their tumor mass (also known as tumor burden) had been drastically reduced by the therapies they had received, and this in turn dramatically increased the likelihood that Macrophage activation would remove the remaining cancer cells.

We have not observed adverse effects in such a context and we feel safe to state that it can be considered in many cases as a valid complementary approach to other anticancer therapies.


The Yamamoto Papers

Dr Yamamoto was the first but since then many other papers have been published on the subject of activating macrophages using Vitamin D. However Dr Yamamoto was the first to trial Macrophage activation in humans. In all papers he can be quoted

"Stepwise treatment of purified Gc protein with immobilized beta-galactosidase and sialidase generated the most potent macrophage-activating factor (Macrophage activation) ever discovered, but it produces no side effect in humans."

• Dr. Yamamoto’s 2008 breast cancer paper entitled: “Immunotherapy of metastatic breast cancer patients with vitamin D-binding protein-derived macrophage activating factor (Macrophage activation).” (This is an abstract. You can access the full paper by clicking in upper right-hand corner.)

• Dr. Yamamoto’s 2008 prostate cancer paper entitled: “Immunotherapy for Prostate Cancer with Gc Protein-Derived Macrophage-Activating Factor, Macrophage activation.”

• Dr. Yamamoto’s 2008 colorectal cancer paper entitled: “Immunotherapy of metastatic colorectal cancer with vitamin D-binding protein-derived macrophage-activating factor, Macrophage activation.” (This is an abstract. You can access the full paper by clicking in upper right-hand corner.)

• Dr. Yamamoto’s 2008 HIV paper entitled: “Immunotherapy of HIV-Infected Patients With Gc Protein-Derived Macrophage Activating Factor (Macrophage activation).”